Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
نویسندگان
چکیده
منابع مشابه
The Use of Blood Cell Gene Expression Profiles as a Surrogates for Target Organ Toxicity
Microarray analysis of mRNA changes due to up-regulated and down-regulated polymorphonulear leucocyte (PMNL) gene responses to toxicant exposure have been proposed to permit the assessment of toxicant visceral tissue effects and gene responses in rodent models and human exposure situations. The use of PMNL as surrogates for toxicant target organs such as lung, brain and liver has been used to d...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2008
ISSN: 1465-6906
DOI: 10.1186/gb-2008-9-6-r100